Assay Detail
Binding
CHEMBL643406
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity towards alpha-1 adrenergic receptor by using [3H]prazosin in rat brain cortex membranes.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
A structure-affinity relationship study on derivatives of N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide, a high-affinity and selective D(4) receptor ligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 6.36 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92713 | — | — | 1 | 6.36 |
| CHEMBL96462 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92713 | — | Ki | = | 437.0 | nM | 6.36 |
| CHEMBL96462 | — | Ki | > | 850.0 | nM | - |