Assay Detail
Binding
CHEMBL643448
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In vitro inhibitory activity against alpha-1 adrenergic receptor binding to rat brain membranes
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
NR2B-selective N-methyl-D-aspartate antagonists: synthesis and evaluation of 5-substituted benzimidazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.73 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63200 | — | — | 1 | 6.70 |
| CHEMBL67196 | — | — | 1 | 6.28 |
| CHEMBL303832 | — | — | 1 | 6.28 |
| CHEMBL65039 | — | — | 1 | 6.24 |
| CHEMBL64941 | — | — | 1 | 6.21 |
| CHEMBL65231 | — | — | 1 | 6.17 |
| CHEMBL68134 | — | — | 1 | 6.14 |
| CHEMBL416690 | — | — | 1 | 6.08 |
| CHEMBL63146 | — | — | 1 | 5.92 |
| CHEMBL436521 | — | — | 1 | 5.82 |
| CHEMBL61895 | — | — | 1 | 5.70 |
| CHEMBL65454 | — | — | 1 | 5.58 |
| CHEMBL65119 | — | — | 1 | 5.58 |
| CHEMBL304070 | — | — | 1 | 5.55 |
| CHEMBL65314 | — | — | 1 | 5.55 |
| CHEMBL304274 | — | — | 1 | 5.51 |
| CHEMBL63474 | — | — | 1 | 5.47 |
| CHEMBL65693 | — | — | 1 | 5.40 |
| CHEMBL67249 | — | — | 1 | 5.38 |
| CHEMBL63992 | — | — | 1 | 5.32 |
| CHEMBL63924 | — | — | 1 | 5.26 |
| CHEMBL66539 | — | — | 1 | 4.85 |
| CHEMBL65245 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63200 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL67196 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL303832 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL65039 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL64941 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL65231 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL68134 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL416690 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL63146 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL436521 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL61895 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL65454 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL65119 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL304070 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL65314 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL304274 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL63474 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL65693 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL67249 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL63992 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL63924 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL66539 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL65245 | — | IC50 | = | 20000.0 | nM | 4.70 |