Assay Detail
Binding
CHEMBL643449
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Inhibition of [3H]WB-4101 binding to rat cortical Alpha-1 adrenergic receptor in vitro
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and biological characterization of alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.70 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140872 | — | — | 1 | 8.22 |
| CHEMBL141226 | — | — | 1 | 7.66 |
| CHEMBL140656 | — | — | 1 | 7.54 |
| CHEMBL137870 | — | — | 1 | 7.29 |
| CHEMBL479 | THIORIDAZINE | 4.0 | 1 | 7.19 |
| CHEMBL141922 | — | — | 1 | 7.14 |
| CHEMBL141455 | — | — | 1 | 7.02 |
| CHEMBL335348 | — | — | 1 | 6.79 |
| CHEMBL141854 | — | — | 1 | 6.75 |
| CHEMBL334934 | — | — | 1 | 6.64 |
| CHEMBL443482 | — | — | 1 | 6.58 |
| CHEMBL140650 | — | — | 1 | 6.52 |
| CHEMBL342484 | — | — | 1 | 6.43 |
| CHEMBL140831 | — | — | 1 | 6.40 |
| CHEMBL137967 | — | — | 1 | 6.35 |
| CHEMBL60859 | BMY-14802 | — | 1 | 6.28 |
| CHEMBL344577 | — | — | 1 | 6.12 |
| CHEMBL140712 | — | — | 1 | 6.09 |
| CHEMBL138186 | — | — | 1 | 5.94 |
| CHEMBL139595 | — | — | 1 | 5.85 |
| CHEMBL141670 | — | — | 1 | 5.82 |
| CHEMBL140833 | — | — | 1 | - |
| CHEMBL141523 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140872 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL141226 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL140656 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL137870 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL479 | THIORIDAZINE | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL141922 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL141455 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL335348 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL141854 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL334934 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL443482 | — | IC50 | = | 266.0 | nM | 6.58 |
| CHEMBL140650 | — | IC50 | = | 305.0 | nM | 6.52 |
| CHEMBL342484 | — | IC50 | = | 375.0 | nM | 6.43 |
| CHEMBL140831 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL137967 | — | IC50 | = | 446.0 | nM | 6.35 |
| CHEMBL60859 | BMY-14802 | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL344577 | — | IC50 | = | 756.0 | nM | 6.12 |
| CHEMBL140712 | — | IC50 | = | 814.0 | nM | 6.09 |
| CHEMBL138186 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL139595 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL141670 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL140833 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL141523 | — | IC50 | > | 1000.0 | nM | - |