Assay Detail
Binding
CHEMBL643474
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Binding affinity against adenosine A1 receptor of rat brain cortical membranes using [3H]CHA
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, A(2A)-selective adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.99 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL138080 | — | — | 1 | 6.20 |
| CHEMBL413079 | — | — | 1 | 6.05 |
| CHEMBL138396 | — | — | 1 | 6.03 |
| CHEMBL343175 | — | — | 1 | 5.98 |
| CHEMBL139090 | — | — | 1 | 5.97 |
| CHEMBL136047 | — | — | 1 | 5.92 |
| CHEMBL138527 | — | — | 1 | 5.89 |
| CHEMBL344857 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL138080 | — | Ki | = | 625.0 | nM | 6.20 |
| CHEMBL413079 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL138396 | — | Ki | = | 940.0 | nM | 6.03 |
| CHEMBL343175 | — | Ki | = | 1040.0 | nM | 5.98 |
| CHEMBL139090 | — | Ki | = | 1070.0 | nM | 5.97 |
| CHEMBL136047 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL138527 | — | Ki | = | 1280.0 | nM | 5.89 |
| CHEMBL344857 | — | Ki | = | 1280.0 | nM | 5.89 |