Assay Detail
Binding
CHEMBL643483
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity at A1 adenosine receptor in rat brain cortical membrane using [3H]- N6-R-phenylisopropyladenosine (R-PIA)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationships at adenosine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.65 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325959 | — | — | 1 | 7.17 |
| CHEMBL274855 | — | — | 1 | 7.17 |
| CHEMBL285191 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325959 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL274855 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL285191 | — | Ki | = | 2500.0 | nM | 5.60 |