Assay Detail
Binding
CHEMBL643486
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Binding affinity at rat Adenosine A1 receptor in the presence of GTP
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
5'-Deoxy congeners of 9-(3-amido-3-deoxy-beta-D-xylofuranosyl)-N(6)-cyclopentyladenine: new adenosine A(1) receptor antagonists and inverse agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.16 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | — | 1 | 8.92 |
| CHEMBL52648 | — | — | 1 | 7.77 |
| CHEMBL296399 | — | — | 1 | 7.42 |
| CHEMBL54334 | — | — | 1 | 7.34 |
| CHEMBL293371 | — | — | 1 | 7.27 |
| CHEMBL53795 | — | — | 1 | 7.16 |
| CHEMBL55195 | — | — | 1 | 6.94 |
| CHEMBL299238 | — | — | 1 | 6.68 |
| CHEMBL48278 | — | — | 1 | 6.59 |
| CHEMBL54468 | — | — | 1 | 6.35 |
| CHEMBL299504 | — | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL52648 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL296399 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL54334 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL293371 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL53795 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL55195 | — | Ki | = | 114.0 | nM | 6.94 |
| CHEMBL299238 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL48278 | — | Ki | = | 259.0 | nM | 6.59 |
| CHEMBL54468 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL299504 | — | Ki | = | 470.0 | nM | 6.33 |