Assay Detail
Binding
CHEMBL643491
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Binding affinity against Human recombinant Adenosine A1 receptor stably transfected in CHO cells using [3H]CCPA as radioligand
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 7.86 | 9.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408918 | — | — | 1 | 9.36 |
| CHEMBL2092941 | — | — | 1 | 9.17 |
| CHEMBL262363 | — | — | 1 | 9.17 |
| CHEMBL438418 | — | — | 1 | 8.96 |
| CHEMBL2092787 | — | — | 1 | 8.82 |
| CHEMBL259938 | — | — | 1 | 8.77 |
| CHEMBL258534 | — | — | 1 | 8.72 |
| CHEMBL224874 | — | — | 1 | 8.68 |
| CHEMBL410095 | — | — | 1 | 8.66 |
| CHEMBL2092788 | — | — | 1 | 8.57 |
| CHEMBL2094083 | — | — | 1 | 8.57 |
| CHEMBL258535 | — | — | 1 | 8.47 |
| CHEMBL410115 | — | — | 1 | 8.15 |
| CHEMBL2092786 | — | — | 1 | 8.08 |
| CHEMBL261453 | — | — | 1 | 8.02 |
| CHEMBL319387 | — | — | 1 | 7.75 |
| CHEMBL261623 | — | — | 1 | 7.37 |
| CHEMBL3350613 | — | — | 1 | 7.22 |
| CHEMBL437842 | — | — | 1 | 6.86 |
| CHEMBL260563 | — | — | 1 | 6.49 |
| CHEMBL375190 | — | — | 1 | 6.41 |
| CHEMBL2113551 | — | — | 1 | 6.37 |
| CHEMBL223270 | — | — | 1 | 6.25 |
| CHEMBL607759 | — | — | 1 | 5.93 |
| CHEMBL574597 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408918 | — | Ki | = | 0.44 | nM | 9.36 |
| CHEMBL2092941 | — | Ki | = | 0.67 | nM | 9.17 |
| CHEMBL262363 | — | Ki | = | 0.67 | nM | 9.17 |
| CHEMBL438418 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL2092787 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL259938 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL258534 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL224874 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL410095 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL2092788 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL2094083 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL258535 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL410115 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL2092786 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL261453 | — | Ki | = | 9.6 | nM | 8.02 |
| CHEMBL319387 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL261623 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL3350613 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL437842 | — | Ki | = | 138.0 | nM | 6.86 |
| CHEMBL260563 | — | Ki | = | 327.0 | nM | 6.49 |
| CHEMBL375190 | — | Ki | = | 391.0 | nM | 6.41 |
| CHEMBL2113551 | — | Ki | = | 429.0 | nM | 6.37 |
| CHEMBL223270 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL607759 | — | Ki | = | 1176.0 | nM | 5.93 |
| CHEMBL574597 | — | Ki | = | 1690.0 | nM | 5.77 |