Assay Detail
Binding
CHEMBL643496
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Binding affinity against human adenosine A1 receptor expressed in CHO cells using [3H]DPCPX
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
New, non-adenosine, high-potency agonists for the human adenosine A2B receptor with an improved selectivity profile compared to the reference agonist N-ethylcarboxamidoadenosine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.48 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL125979 | — | — | 1 | 8.70 |
| CHEMBL124345 | — | — | 1 | 8.62 |
| CHEMBL122622 | — | — | 1 | 8.59 |
| CHEMBL122806 | — | — | 1 | 8.36 |
| CHEMBL122396 | — | — | 1 | 8.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL125979 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL124345 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL122622 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL122806 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL122396 | — | Ki | = | 7.0 | nM | 8.15 |