Assay Detail
Binding
CHEMBL643498
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Binding affinity at human Adenosine A1 receptor expressed in CHO cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
5'-Deoxy congeners of 9-(3-amido-3-deoxy-beta-D-xylofuranosyl)-N(6)-cyclopentyladenine: new adenosine A(1) receptor antagonists and inverse agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.53 | 8.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | — | 1 | 8.67 |
| CHEMBL52648 | — | — | 1 | 6.86 |
| CHEMBL296399 | — | — | 1 | 6.38 |
| CHEMBL294675 | — | — | 1 | 6.35 |
| CHEMBL293371 | — | — | 1 | 6.24 |
| CHEMBL54334 | — | — | 1 | 6.20 |
| CHEMBL55099 | — | — | 1 | 6.11 |
| CHEMBL53795 | — | — | 1 | 6.01 |
| CHEMBL48278 | — | — | 1 | 5.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | Ki | = | 2.13 | nM | 8.67 |
| CHEMBL52648 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL296399 | — | Ki | = | 419.0 | nM | 6.38 |
| CHEMBL294675 | — | Ki | = | 443.0 | nM | 6.35 |
| CHEMBL293371 | — | Ki | = | 579.0 | nM | 6.24 |
| CHEMBL54334 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL55099 | — | Ki | = | 773.0 | nM | 6.11 |
| CHEMBL53795 | — | Ki | = | 971.0 | nM | 6.01 |
| CHEMBL48278 | — | Ki | = | 1185.0 | nM | 5.93 |