Assay Detail
Binding
CHEMBL643511
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The binding affinity at the Alpha-2 adrenergic receptor determined using [3H]RX-821002; Not tested
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.00 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109877 | — | — | 1 | 6.00 |
| CHEMBL334270 | — | — | 1 | 6.00 |
| CHEMBL324270 | — | — | 1 | - |
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | - |
| CHEMBL654 | MIRTAZAPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109877 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL334270 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL324270 | — | Ki | - | — | - | |
| CHEMBL6437 | MIANSERIN | Ki | - | — | - | |
| CHEMBL654 | MIRTAZAPINE | Ki | - | — | - |