Assay Detail
Binding
CHEMBL643523
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Binding affinity towards Alpha-1 adrenergic receptor in human brain
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Analogs of UK 14,304 as 2-adrenoceptor agonists. Twist and agent polarity as design elements.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.42 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74283 | — | — | 1 | 5.96 |
| CHEMBL49137 | — | — | 1 | 5.85 |
| CHEMBL342029 | — | — | 1 | 5.29 |
| CHEMBL49284 | — | — | 1 | 5.06 |
| CHEMBL49395 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74283 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL49137 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL342029 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL49284 | — | Ki | = | 8700.0 | nM | 5.06 |
| CHEMBL49395 | — | Ki | = | 11000.0 | nM | 4.96 |