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Assay Detail

CHEMBL643525

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards human alpha-1 adrenergic receptor
ChEMBL ↗
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Adrenergic receptor alpha-1 (CHEMBL2094251) ↗
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Current and novel approaches to the drug treatment of schizophrenia.
Rowley M, Bristow LJ, Hutson PH.
J Med Chem (2001) 44 : 477 -501
PubMed 11170639 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 5 8.56 9.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL85 RISPERIDONE 4.0 1 9.16
CHEMBL708 ZIPRASIDONE 4.0 1 8.72
CHEMBL42 CLOZAPINE 4.0 1 8.43
CHEMBL716 QUETIAPINE 4.0 1 8.35
CHEMBL715 OLANZAPINE 4.0 1 8.14

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL85 RISPERIDONE Ki = 0.69 nM 9.16
CHEMBL708 ZIPRASIDONE Ki = 1.9 nM 8.72
CHEMBL42 CLOZAPINE Ki = 3.7 nM 8.43
CHEMBL716 QUETIAPINE Ki = 4.5 nM 8.35
CHEMBL715 OLANZAPINE Ki = 7.3 nM 8.14