Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL643533

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
pA2 for Alpha-1 adrenergic receptor from human prostate.
18
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Prostate gland
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Adrenergic receptor alpha-1 (CHEMBL2094251)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Pharmacological options in the treatment of benign prostatic hyperplasia.
Kenny B, Ballard S, Blagg J, Fox D.
J Med Chem (1997) 40 : 1293 -1315
PubMed 9135028 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 18 8.26 9.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL836 TAMSULOSIN 4.0 3 9.80
CHEMBL25554 1 8.90
CHEMBL24777 1 8.80
CHEMBL278865 UPIDOSIN 2.0 1 8.80
CHEMBL279516 INDORAMIN 2.0 1 8.70
CHEMBL2 PRAZOSIN 4.0 1 8.70
CHEMBL24981 1 8.60
CHEMBL420060 1 8.20
CHEMBL707 DOXAZOSIN 4.0 1 8.20
CHEMBL286591 1 7.90
CHEMBL25467 1 7.50
CHEMBL611 TERAZOSIN 4.0 1 7.40
CHEMBL2051956 DEXNIGULDIPINE 2.0 1 7.30
CHEMBL88272 1 7.30
CHEMBL543741 1 6.40
CHEMBL5483012 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL836 TAMSULOSIN Kd = 0.1585 nM 9.80
CHEMBL836 TAMSULOSIN Kd = 0.1585 nM 9.80
CHEMBL25554 Kd = 1.259 nM 8.90
CHEMBL278865 UPIDOSIN Kd = 1.585 nM 8.80
CHEMBL24777 Kd = 1.585 nM 8.80
CHEMBL2 PRAZOSIN Kd = 1.995 nM 8.70
CHEMBL279516 INDORAMIN Kd = 1.995 nM 8.70
CHEMBL24981 Kd = 2.512 nM 8.60
CHEMBL836 TAMSULOSIN Kd = 6.31 nM 8.20
CHEMBL420060 Kd = 6.31 nM 8.20
CHEMBL707 DOXAZOSIN Kd = 6.31 nM 8.20
CHEMBL286591 Kd = 12.59 nM 7.90
CHEMBL25467 Kd = 31.62 nM 7.50
CHEMBL611 TERAZOSIN Kd = 39.81 nM 7.40
CHEMBL88272 Kd = 50.12 nM 7.30
CHEMBL2051956 DEXNIGULDIPINE Kd = 50.12 nM 7.30
CHEMBL543741 Kd = 398.11 nM 6.40
CHEMBL5483012 Kd > 316.23 nM -