Assay Detail
Functional
CHEMBL643535
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity against Alpha-1 adrenergic receptor subtypes of human prostate tissue
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
N-arylpiperazinyl-N'-propylamino derivatives of heteroaryl amides as functional uroselective alpha 1-adrenoceptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 8.48 | 10.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL836 | TAMSULOSIN | 4.0 | 1 | 10.40 |
| CHEMBL90874 | — | — | 1 | 8.70 |
| CHEMBL2 | PRAZOSIN | 4.0 | 1 | 8.70 |
| CHEMBL420060 | — | — | 1 | 8.20 |
| CHEMBL611 | TERAZOSIN | 4.0 | 1 | 7.60 |
| CHEMBL88272 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL836 | TAMSULOSIN | Kd | = | 0.03981 | nM | 10.40 |
| CHEMBL90874 | — | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL2 | PRAZOSIN | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL420060 | — | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL611 | TERAZOSIN | Kd | = | 25.12 | nM | 7.60 |
| CHEMBL88272 | — | Kd | = | 50.12 | nM | 7.30 |