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Assay Detail

CHEMBL643544

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant human adenosine kinase
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Adenosine kinase (CHEMBL3589)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Adenosine kinase inhibitors. 2. Synthesis, enzyme inhibition, and antiseizure activity of diaryltubercidin analogues.
Ugarkar BG, Castellino AJ, DaRe JM, Kopcho JJ, Wiesner JB, Schanzer JM, Erion MD.
J Med Chem (2000) 43 : 2894 -2905
PubMed 10956197 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 34 7.61 9.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL100421 1 9.30
CHEMBL319315 1 9.10
CHEMBL317603 1 9.00
CHEMBL98551 1 9.00
CHEMBL328826 1 9.00
CHEMBL318918 1 8.92
CHEMBL66277 1 8.82
CHEMBL318929 1 8.82
CHEMBL98867 1 8.82
CHEMBL317818 1 8.64
CHEMBL432062 1 8.57
CHEMBL99565 1 8.44
CHEMBL98744 1 8.22
CHEMBL99829 1 8.20
CHEMBL99025 1 8.05
CHEMBL318645 1 7.85
CHEMBL99536 1 7.60
CHEMBL100262 1 7.58
CHEMBL316668 1 7.52
CHEMBL442002 1 7.36
CHEMBL99062 1 7.33
CHEMBL318281 1 7.00
CHEMBL319611 1 7.00
CHEMBL317176 1 6.92
CHEMBL442003 1 6.70
CHEMBL98174 1 6.60
CHEMBL330221 1 6.52
CHEMBL329484 1 6.50
CHEMBL431628 1 6.26
CHEMBL98887 1 6.11

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL100421 IC50 = 0.5 nM 9.30
CHEMBL319315 IC50 = 0.8 nM 9.10
CHEMBL317603 IC50 = 1.0 nM 9.00
CHEMBL98551 IC50 = 1.0 nM 9.00
CHEMBL328826 IC50 = 1.0 nM 9.00
CHEMBL318918 IC50 = 1.2 nM 8.92
CHEMBL66277 IC50 = 1.5 nM 8.82
CHEMBL318929 IC50 = 1.5 nM 8.82
CHEMBL98867 IC50 = 1.5 nM 8.82
CHEMBL317818 IC50 = 2.3 nM 8.64
CHEMBL432062 IC50 = 2.7 nM 8.57
CHEMBL99565 IC50 = 3.6 nM 8.44
CHEMBL98744 IC50 = 6.0 nM 8.22
CHEMBL99829 IC50 = 6.3 nM 8.20
CHEMBL99025 IC50 = 9.0 nM 8.05
CHEMBL318645 IC50 = 14.0 nM 7.85
CHEMBL99536 IC50 = 25.0 nM 7.60
CHEMBL100262 IC50 = 26.0 nM 7.58
CHEMBL316668 IC50 = 30.0 nM 7.52
CHEMBL442002 IC50 = 44.0 nM 7.36
CHEMBL99062 IC50 = 47.0 nM 7.33
CHEMBL318281 IC50 = 100.0 nM 7.00
CHEMBL319611 IC50 = 100.0 nM 7.00
CHEMBL317176 IC50 = 120.0 nM 6.92
CHEMBL442003 IC50 = 200.0 nM 6.70
CHEMBL98174 IC50 = 250.0 nM 6.60
CHEMBL330221 IC50 = 300.0 nM 6.52
CHEMBL329484 IC50 = 320.0 nM 6.50
CHEMBL431628 IC50 = 550.0 nM 6.26
CHEMBL98887 IC50 = 775.0 nM 6.11
CHEMBL317583 IC50 = 800.0 nM 6.10
CHEMBL99923 IC50 = 1200.0 nM 5.92
CHEMBL98424 IC50 = 1250.0 nM 5.90
CHEMBL319338 IC50 = 10000.0 nM 5.00