Assay Detail
Binding
CHEMBL643545
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Inhibitory activity against human adenosine kinase expressed in Escherichia coli
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery and optimization of 2-aryl oxazolo-pyrimidines as adenosine kinase inhibitors using liquid phase parallel synthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 7.23 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL174158 | — | — | 1 | 9.00 |
| CHEMBL360273 | — | — | 1 | 8.82 |
| CHEMBL66089 | — | — | 1 | 8.00 |
| CHEMBL366539 | — | — | 1 | 8.00 |
| CHEMBL174700 | — | — | 1 | 7.52 |
| CHEMBL368401 | — | — | 1 | 7.40 |
| CHEMBL175074 | — | — | 1 | 7.40 |
| CHEMBL362464 | — | — | 1 | 7.30 |
| CHEMBL174992 | — | — | 1 | 7.22 |
| CHEMBL175440 | — | — | 1 | 7.16 |
| CHEMBL175041 | — | — | 1 | 7.16 |
| CHEMBL361797 | — | — | 1 | 7.16 |
| CHEMBL425500 | — | — | 1 | 7.05 |
| CHEMBL424966 | — | — | 1 | 7.05 |
| CHEMBL175809 | — | — | 1 | 6.92 |
| CHEMBL369761 | — | — | 1 | 6.89 |
| CHEMBL366606 | — | — | 1 | 6.89 |
| CHEMBL177540 | — | — | 1 | 6.70 |
| CHEMBL176718 | — | — | 1 | 6.70 |
| CHEMBL369435 | — | — | 1 | 6.68 |
| CHEMBL366694 | — | — | 1 | 6.64 |
| CHEMBL355801 | — | — | 1 | 6.62 |
| CHEMBL367498 | — | — | 1 | 6.58 |
| CHEMBL425507 | — | — | 1 | 6.57 |
| CHEMBL177317 | — | — | 1 | - |
| CHEMBL177314 | — | — | 1 | - |
| CHEMBL366908 | — | — | 1 | - |
| CHEMBL175626 | — | — | 1 | - |
| CHEMBL177368 | — | — | 1 | - |
| CHEMBL368003 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL174158 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL360273 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL66089 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL366539 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL174700 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL368401 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL175074 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL362464 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL174992 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL175440 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL175041 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL361797 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL425500 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL424966 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL175809 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL369761 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL366606 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL177540 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL176718 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL369435 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL366694 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL355801 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL367498 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL425507 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL177663 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL177680 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL435552 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL369374 | — | IC50 | > | 1.0 | nM | - |
| CHEMBL177664 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL368003 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL177368 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL175626 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL366908 | — | IC50 | > | 1.0 | nM | - |
| CHEMBL177314 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL177317 | — | IC50 | > | 10.0 | nM | - |