Assay Detail
Binding
CHEMBL643553
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In vitro inhibition of Adenosine kinase (AK)
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor..
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.14 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL66280 | 5-IODO,5'-DEOXYTUBERCIDIN | — | 1 | 8.80 |
| CHEMBL66089 | — | — | 1 | 8.77 |
| CHEMBL68748 | — | — | 1 | 8.74 |
| CHEMBL66277 | — | — | 1 | 8.55 |
| CHEMBL68749 | — | — | 1 | 8.30 |
| CHEMBL68492 | — | — | 1 | 8.15 |
| CHEMBL302921 | — | — | 1 | 8.08 |
| CHEMBL302376 | — | — | 1 | 7.82 |
| CHEMBL305746 | — | — | 1 | 7.60 |
| CHEMBL66568 | — | — | 1 | 7.20 |
| CHEMBL416498 | — | — | 1 | 7.18 |
| CHEMBL66977 | — | — | 1 | 7.13 |
| CHEMBL302938 | — | — | 1 | 7.04 |
| CHEMBL65852 | — | — | 1 | 6.40 |
| CHEMBL66338 | — | — | 1 | 6.36 |
| CHEMBL303499 | — | — | 1 | 6.11 |
| CHEMBL67043 | — | — | 1 | 5.76 |
| CHEMBL304179 | — | — | 1 | 5.70 |
| CHEMBL67267 | — | — | 1 | 5.70 |
| CHEMBL308008 | — | — | 1 | 5.32 |
| CHEMBL419063 | — | — | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL66280 | 5-IODO,5'-DEOXYTUBERCIDIN | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL66089 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL68748 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL66277 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL68749 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL68492 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL302921 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL302376 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL305746 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL66568 | — | IC50 | = | 62.5 | nM | 7.20 |
| CHEMBL416498 | — | IC50 | = | 66.7 | nM | 7.18 |
| CHEMBL66977 | — | IC50 | = | 73.3 | nM | 7.13 |
| CHEMBL302938 | — | IC50 | = | 91.7 | nM | 7.04 |
| CHEMBL65852 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL66338 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL303499 | — | IC50 | = | 773.0 | nM | 6.11 |
| CHEMBL67043 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL304179 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL67267 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL308008 | — | IC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL419063 | — | IC50 | = | 5500.0 | nM | 5.26 |