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Compound Detail

CHEMBL66280

5-IODO,5'-DEOXYTUBERCIDIN
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C[C@H]1O[C@@H](n2cc(I)c3c(N)ncnc32)[C@H](O)[C@@H]1O

Basic Information

ChEMBL ID CHEMBL66280
Name 5-IODO,5'-DEOXYTUBERCIDIN
Phase Preclinical
Structure Type MOL
InChI Key NTXUAWGNGBSCRS-TZQXKBMNSA-N
2
Targets
9
Activities
1
Assay Types
0
PK Parameters
11
Publications
0
Known Names

Molecular Properties

376.1
MW (Da)
0.26
ALogP
7
HBA
3
HBD
106.4
PSA (Ų)
0.62
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C11H13IN4O3
MW 376.15
Aromatic Rings 2
Heavy Atoms 19
NP-Likeness 0.83

Activity Summary

IC50 9 meas. best 9.05

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine kinase
CHEMBL3589
IC50 9.05 8.1483 0.9 6
Adenosine kinase
CHEMBL2384
IC50 8.8 8.795 1.6 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
11405650 10.1021/jm000314x Adenosine kinase 2
11958989 10.1016/s0960-894x(02)00042-2 Adenosine kinase 1
11549437 10.1016/s0960-894x(01)00454-1 Adenosine kinase 1
15149648 10.1016/j.bmcl.2004.04.040 Adenosine kinase 1
10956196 10.1021/jm000024g Adenosine kinase 1
10956196 10.1021/jm000024g Rattus norvegicus 1
16190769 10.1021/jm0503650 Adenosine kinase 1
17154503 10.1021/jm060189a Adenosine kinase 1
18359230 10.1016/j.bmc.2008.03.027 Adenosine kinase 1
- 10.1007/s00044-004-0048-0 Adenosine kinase 1
27410258 10.1021/acs.jmedchem.6b00689 Adenosine kinase 1

Data from ChEMBL 36 via Core Engine