Assay Detail
Binding
CHEMBL642225
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Inhibition of recombinant human adenosine kinase
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Adenosine kinase inhibitors. 1. Synthesis, enzyme inhibition, and antiseizure activity of 5-iodotubercidin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 6.81 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL330432 | — | — | 1 | 10.00 |
| CHEMBL99707 | — | — | 1 | 9.70 |
| CHEMBL322611 | — | — | 1 | 9.22 |
| CHEMBL329724 | — | — | 1 | 8.52 |
| CHEMBL449407 | — | — | 1 | 8.05 |
| CHEMBL66280 | 5-IODO,5'-DEOXYTUBERCIDIN | — | 1 | 8.05 |
| CHEMBL328824 | — | — | 1 | 7.62 |
| CHEMBL99203 | IODOTUBERCIDIN | — | 1 | 7.58 |
| CHEMBL318043 | — | — | 1 | 7.46 |
| CHEMBL98909 | — | — | 1 | 7.40 |
| CHEMBL95481 | — | — | 1 | 7.35 |
| CHEMBL98910 | — | — | 1 | 7.30 |
| CHEMBL97494 | — | — | 1 | 7.22 |
| CHEMBL97437 | — | — | 1 | 7.20 |
| CHEMBL318056 | — | — | 1 | 7.16 |
| CHEMBL99119 | — | — | 1 | 7.00 |
| CHEMBL97553 | — | — | 1 | 7.00 |
| CHEMBL62099 | — | — | 1 | 6.92 |
| CHEMBL302376 | — | — | 1 | 6.77 |
| CHEMBL98933 | — | — | 1 | 6.68 |
| CHEMBL99388 | — | — | 1 | 6.51 |
| CHEMBL99668 | TOYOCAMYCIN | — | 1 | 6.51 |
| CHEMBL99359 | — | — | 1 | 6.35 |
| CHEMBL98638 | — | — | 1 | 6.34 |
| CHEMBL101892 | SANGIVAMYCIN | — | 1 | 6.33 |
| CHEMBL95721 | — | — | 1 | 6.30 |
| CHEMBL99662 | — | — | 1 | 6.27 |
| CHEMBL419517 | — | — | 1 | 6.00 |
| CHEMBL95211 | — | — | 1 | 6.00 |
| CHEMBL95256 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL330432 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL99707 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL322611 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL329724 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL449407 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL66280 | 5-IODO,5'-DEOXYTUBERCIDIN | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL328824 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL99203 | IODOTUBERCIDIN | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL318043 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL98909 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL95481 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL98910 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL97494 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL97437 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL318056 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL99119 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL97553 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL62099 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL302376 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL98933 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL99668 | TOYOCAMYCIN | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL99388 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL99359 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL98638 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL101892 | SANGIVAMYCIN | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL95721 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL99662 | — | IC50 | = | 535.0 | nM | 6.27 |
| CHEMBL95256 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL95211 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL419517 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL319177 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL322217 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL317927 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL95482 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL95608 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL420640 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL267099 | TUBERCIDIN | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL98641 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL318634 | — | IC50 | = | 16500.0 | nM | 4.78 |