Assay Detail
Binding
CHEMBL912349
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Inhibition of human cytosolic AK
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Crystal structures of human adenosine kinase inhibitor complexes reveal two distinct binding modes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.84 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL66280 | 5-IODO,5'-DEOXYTUBERCIDIN | — | 1 | 9.05 |
| CHEMBL338508 | — | — | 1 | 8.60 |
| CHEMBL386316 | — | — | 1 | 8.05 |
| CHEMBL216119 | — | — | 1 | 7.70 |
| CHEMBL420879 | — | — | 1 | 7.40 |
| CHEMBL216697 | — | — | 1 | 7.17 |
| CHEMBL119839 | — | — | 1 | 6.92 |
| CHEMBL276470 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL66280 | 5-IODO,5'-DEOXYTUBERCIDIN | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL338508 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL386316 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL216119 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL420879 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL216697 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL119839 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL276470 | — | IC50 | > | 1000.0 | nM | - |