Assay Detail
Functional
CHEMBL700683
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of adenosine phosphorylation in confluent IMR-32 (human neuroblastoma) cells.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | IMR-32 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor..
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.34 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL66280 | 5-IODO,5'-DEOXYTUBERCIDIN | — | 1 | 7.64 |
| CHEMBL68748 | — | — | 1 | 7.50 |
| CHEMBL66089 | — | — | 1 | 7.30 |
| CHEMBL66277 | — | — | 1 | 6.87 |
| CHEMBL68749 | — | — | 1 | 6.78 |
| CHEMBL305746 | — | — | 1 | 6.48 |
| CHEMBL68492 | — | — | 1 | 6.33 |
| CHEMBL302921 | — | — | 1 | 6.33 |
| CHEMBL66977 | — | — | 1 | 6.30 |
| CHEMBL302938 | — | — | 1 | 6.25 |
| CHEMBL416498 | — | — | 1 | 6.16 |
| CHEMBL65852 | — | — | 1 | 6.00 |
| CHEMBL66338 | — | — | 1 | 5.44 |
| CHEMBL302376 | — | — | 1 | 5.20 |
| CHEMBL304179 | — | — | 1 | 4.58 |
| CHEMBL303499 | — | — | 1 | - |
| CHEMBL67043 | — | — | 1 | - |
| CHEMBL67267 | — | — | 1 | - |
| CHEMBL66568 | — | — | 1 | - |
| CHEMBL419063 | — | — | 1 | - |
| CHEMBL308008 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL66280 | 5-IODO,5'-DEOXYTUBERCIDIN | IC50 | = | 22.8 | nM | 7.64 |
| CHEMBL68748 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL66089 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL66277 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL68749 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL305746 | — | IC50 | = | 333.0 | nM | 6.48 |
| CHEMBL68492 | — | IC50 | = | 467.0 | nM | 6.33 |
| CHEMBL302921 | — | IC50 | = | 467.0 | nM | 6.33 |
| CHEMBL66977 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL302938 | — | IC50 | = | 567.0 | nM | 6.25 |
| CHEMBL416498 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL65852 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL66338 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL302376 | — | IC50 | = | 6330.0 | nM | 5.20 |
| CHEMBL304179 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL303499 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL67043 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL67267 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL66568 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL419063 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL308008 | — | IC50 | > | 10000.0 | nM | - |