Assay Detail
Binding
CHEMBL643602
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of specific binding of [125 I] A II to rat liver membrane.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Angiotensin II receptor (AT-1) type-1 (CHEMBL2094250) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Pyrido[2,3-d]pyrimidine angiotensin II antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.86 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL150507 | — | — | 1 | 8.89 |
| CHEMBL153188 | — | — | 1 | 8.87 |
| CHEMBL152957 | — | — | 1 | 8.74 |
| CHEMBL348472 | — | — | 1 | 8.66 |
| CHEMBL152958 | — | — | 1 | 8.64 |
| CHEMBL440731 | — | — | 1 | 8.52 |
| CHEMBL345528 | — | — | 1 | 8.49 |
| CHEMBL432162 | TASOSARTAN | 2.0 | 1 | 8.28 |
| CHEMBL153472 | — | — | 1 | 7.89 |
| CHEMBL346420 | — | — | 1 | 7.64 |
| CHEMBL155163 | — | — | 1 | 7.61 |
| CHEMBL347320 | — | — | 1 | 7.61 |
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 7.46 |
| CHEMBL433930 | — | — | 1 | 7.31 |
| CHEMBL421969 | — | — | 1 | 7.29 |
| CHEMBL150987 | — | — | 1 | 7.07 |
| CHEMBL357998 | — | — | 1 | 7.02 |
| CHEMBL153092 | — | — | 1 | 6.77 |
| CHEMBL153499 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL150507 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL153188 | — | IC50 | = | 1.35 | nM | 8.87 |
| CHEMBL152957 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL348472 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL152958 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL440731 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL345528 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL432162 | TASOSARTAN | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL153472 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL346420 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL155163 | — | IC50 | = | 24.3 | nM | 7.61 |
| CHEMBL347320 | — | IC50 | = | 24.6 | nM | 7.61 |
| CHEMBL191 | LOSARTAN | IC50 | = | 34.7 | nM | 7.46 |
| CHEMBL433930 | — | IC50 | = | 49.4 | nM | 7.31 |
| CHEMBL421969 | — | IC50 | = | 50.7 | nM | 7.29 |
| CHEMBL150987 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL357998 | — | IC50 | = | 94.9 | nM | 7.02 |
| CHEMBL153092 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL153499 | — | IC50 | = | 285.0 | nM | 6.54 |