Assay Detail
Binding
CHEMBL643608
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]- ketanserin from porcine Alpha-1 adrenergic receptor
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Interactive SAR studies: rational discovery of super-potent and highly selective dopamine D3 receptor antagonists and partial agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.67 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL124444 | — | — | 1 | 8.07 |
| CHEMBL141419 | — | — | 1 | 7.82 |
| CHEMBL424294 | — | — | 1 | 7.82 |
| CHEMBL344677 | — | — | 1 | 7.75 |
| CHEMBL336930 | — | — | 1 | 7.72 |
| CHEMBL25236 | BP-897 | — | 1 | 7.60 |
| CHEMBL142020 | — | — | 1 | 7.58 |
| CHEMBL143352 | — | — | 1 | 7.55 |
| CHEMBL342060 | — | — | 1 | 7.50 |
| CHEMBL423735 | — | — | 1 | 7.32 |
| CHEMBL59725 | — | — | 1 | - |
| CHEMBL139926 | — | — | 1 | - |
| CHEMBL337531 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL124444 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL141419 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL424294 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL344677 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL336930 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL25236 | BP-897 | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL142020 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL143352 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL342060 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL423735 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL59725 | — | Ki | > | 2000.0 | nM | - |
| CHEMBL139926 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL337531 | — | Ki | > | 1000.0 | nM | - |