Assay Detail
Binding
CHEMBL643637
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against [3H]WB-4101 binding to Alpha-1 adrenergic receptor in rat whole brain membrane
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.64 | 6.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL154488 | — | — | 1 | 6.29 |
| CHEMBL152842 | — | — | 1 | 5.92 |
| CHEMBL435034 | — | — | 1 | 5.50 |
| CHEMBL154541 | — | — | 1 | 5.48 |
| CHEMBL29835 | BESIPIRDINE | 2.0 | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL154488 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL152842 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL435034 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL154541 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL29835 | BESIPIRDINE | IC50 | = | 10000.0 | nM | 5.00 |