Assay Detail
Binding
CHEMBL643666
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Inhibitory activity against purified rat lens aldose reductase (RLAR)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Molecular modeling studies of aldose reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.12 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10413 | ZENARESTAT | 2.0 | 1 | 8.36 |
| CHEMBL7679 | PONALRESTAT | 2.0 | 1 | 7.80 |
| CHEMBL56337 | EPALRESTAT | 4.0 | 1 | 7.64 |
| CHEMBL164603 | — | — | 1 | 6.89 |
| CHEMBL163888 | — | — | 1 | 6.37 |
| CHEMBL349910 | — | — | 1 | 6.07 |
| CHEMBL63055 | ALRESTATIN | 2.0 | 1 | 5.82 |
| CHEMBL163958 | — | — | 1 | 5.46 |
| CHEMBL44381 | — | — | 1 | 5.05 |
| CHEMBL351278 | — | — | 1 | 4.93 |
| CHEMBL165430 | — | — | 1 | 4.80 |
| CHEMBL422030 | — | — | 1 | 4.25 |
| CHEMBL295321 | — | — | 1 | - |
| CHEMBL353361 | — | — | 1 | - |
| CHEMBL164508 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10413 | ZENARESTAT | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL7679 | PONALRESTAT | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL56337 | EPALRESTAT | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL164603 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL163888 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL349910 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL63055 | ALRESTATIN | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL163958 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL44381 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL351278 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL165430 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL422030 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL295321 | — | IC50 | = | 182000.0 | nM | - |
| CHEMBL353361 | — | IC50 | = | 1488000.0 | nM | - |
| CHEMBL164508 | — | IC50 | = | 217000.0 | nM | - |