Assay Detail
Binding
CHEMBL643667
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against rat lens aldose reductase
2
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis, absolute configuration, and conformation of the aldose reductase inhibitor sorbinil.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.88 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL266497 | SORBINIL | 3.0 | 2 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL266497 | SORBINIL | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL266497 | SORBINIL | IC50 | = | 9000.0 | nM | 5.05 |