Assay Detail
Binding
CHEMBL643668
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against rat lens aldose reductase(AR).
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL2622) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Highly selective aldose reductase inhibitors. 3. Structural diversity of 3-(arylmethyl)-2,4,5-trioxoimidazolidine-1-acetic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.66 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159820 | — | — | 1 | 8.24 |
| CHEMBL162697 | — | — | 1 | 7.96 |
| CHEMBL161043 | — | — | 1 | 7.92 |
| CHEMBL159413 | — | — | 1 | 7.82 |
| CHEMBL355148 | — | — | 1 | 7.80 |
| CHEMBL56337 | EPALRESTAT | 4.0 | 1 | 7.68 |
| CHEMBL349508 | — | — | 1 | 7.62 |
| CHEMBL434076 | — | — | 1 | 7.60 |
| CHEMBL161556 | — | — | 1 | 7.60 |
| CHEMBL433898 | — | — | 1 | 7.50 |
| CHEMBL160032 | — | — | 1 | 7.47 |
| CHEMBL292887 | — | — | 1 | 7.21 |
| CHEMBL159384 | — | — | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159820 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL162697 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL161043 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL159413 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL355148 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL56337 | EPALRESTAT | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL349508 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL434076 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL161556 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL433898 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL160032 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL292887 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL159384 | — | IC50 | = | 62.0 | nM | 7.21 |