Assay Detail
Binding
CHEMBL643678
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards alpha-2 adrenergic receptors in rat brain synaptosomal preparations
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
A new arylpiperazine antipsychotic with high D2/D3/5-HT1A/alpha 1A-adrenergic affinity and a low potential for extrapyramidal effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.20 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10327 | — | — | 1 | 7.80 |
| CHEMBL10085 | MAZAPERTINE | 2.0 | 1 | 7.77 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.24 |
| CHEMBL275045 | — | — | 1 | 6.00 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10327 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL10085 | MAZAPERTINE | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL42 | CLOZAPINE | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL275045 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL54 | HALOPERIDOL | Ki | > | 1000.0 | nM | - |