Assay Detail
Binding
CHEMBL643680
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested in vitro for binding affinity against Alpha-2 adrenergic receptor using [3H]clonidine
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.12 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL287837 | — | — | 1 | 7.68 |
| CHEMBL14346 | 1,2,3,4-TETRAHYDROISOQUINOLINE | — | 1 | 6.46 |
| CHEMBL59994 | — | — | 1 | 6.17 |
| CHEMBL60434 | — | — | 1 | 6.12 |
| CHEMBL38681 | — | — | 1 | 5.35 |
| CHEMBL6409 | CGS-19281A | — | 1 | 4.92 |
| CHEMBL444793 | — | — | 1 | - |
| CHEMBL41647 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL287837 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL14346 | 1,2,3,4-TETRAHYDROISOQUINOLINE | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL59994 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL60434 | — | Ki | = | 760.0 | nM | 6.12 |
| CHEMBL38681 | — | Ki | = | 4500.0 | nM | 5.35 |
| CHEMBL6409 | CGS-19281A | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL444793 | — | Ki | = | 400000.0 | nM | - |
| CHEMBL41647 | — | Ki | = | 1400000.0 | nM | - |