Assay Detail
Binding
CHEMBL643683
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binding affinity towards alpha-2 adrenergic receptor, using [3H]- atipamezole as radioligand from rat frontal cortex membranes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Frontal cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and in vitro evaluation of 2,3-dimethoxy-5-(fluoroalkyl)-substituted benzamides: high-affinity ligands for CNS dopamine D2 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.09 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44237 | EPIDEPRIDE | — | 1 | 8.30 |
| CHEMBL43506 | — | — | 1 | 8.02 |
| CHEMBL42448 | — | — | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44237 | EPIDEPRIDE | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL43506 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL42448 | — | Ki | = | 11.1 | nM | 7.96 |