Assay Detail
Binding
CHEMBL643713
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In vitro binding affinity against alpha-2 adrenergic receptor in rat
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Alpha(2) adrenoceptor agonists as potential analgesic agents. 1. (Imidazolylmethyl)oxazoles and -thiazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 7.37 | 10.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL778 | DEXMEDETOMIDINE | 4.0 | 1 | 10.82 |
| CHEMBL358751 | — | — | 1 | 8.10 |
| CHEMBL145852 | — | — | 1 | 8.00 |
| CHEMBL358415 | — | — | 1 | 7.96 |
| CHEMBL359068 | — | — | 1 | 7.89 |
| CHEMBL358869 | — | — | 1 | 7.77 |
| CHEMBL148566 | — | — | 1 | 7.75 |
| CHEMBL150114 | — | — | 1 | 7.75 |
| CHEMBL144495 | — | — | 1 | 7.75 |
| CHEMBL145857 | — | — | 1 | 7.64 |
| CHEMBL149704 | — | — | 1 | 7.55 |
| CHEMBL342299 | — | — | 1 | 7.55 |
| CHEMBL344743 | — | — | 1 | 7.46 |
| CHEMBL148581 | — | — | 1 | 7.44 |
| CHEMBL358978 | — | — | 1 | 7.43 |
| CHEMBL149376 | — | — | 1 | 7.42 |
| CHEMBL148857 | ENTRY 68 A | — | 1 | 7.28 |
| CHEMBL146085 | — | — | 1 | 7.24 |
| CHEMBL147194 | — | — | 1 | 7.24 |
| CHEMBL423942 | — | — | 1 | 7.22 |
| CHEMBL148701 | — | — | 1 | 7.07 |
| CHEMBL348008 | — | — | 1 | 7.01 |
| CHEMBL147774 | — | — | 1 | 7.01 |
| CHEMBL150185 | — | — | 1 | 6.96 |
| CHEMBL149672 | — | — | 1 | 6.63 |
| CHEMBL148885 | — | — | 1 | 6.57 |
| CHEMBL443289 | — | — | 1 | 6.54 |
| CHEMBL346162 | — | — | 1 | 6.50 |
| CHEMBL150064 | — | — | 1 | 6.42 |
| CHEMBL145914 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL778 | DEXMEDETOMIDINE | Ki | = | 0.015 | nM | 10.82 |
| CHEMBL358751 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL145852 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL358415 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL359068 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL358869 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL148566 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL150114 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL144495 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL145857 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL149704 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL342299 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL344743 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL148581 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL358978 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL149376 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL148857 | ENTRY 68 A | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL146085 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL147194 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL423942 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL148701 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL348008 | — | Ki | = | 97.0 | nM | 7.01 |
| CHEMBL147774 | — | Ki | = | 97.0 | nM | 7.01 |
| CHEMBL150185 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL149672 | — | Ki | = | 235.0 | nM | 6.63 |
| CHEMBL148885 | — | Ki | = | 269.0 | nM | 6.57 |
| CHEMBL443289 | — | Ki | = | 285.0 | nM | 6.54 |
| CHEMBL346162 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL150064 | — | Ki | = | 381.0 | nM | 6.42 |
| CHEMBL145914 | — | Ki | = | 407.0 | nM | 6.39 |
| CHEMBL145972 | — | Ki | = | 714.0 | nM | 6.15 |
| CHEMBL148827 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL147670 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL148160 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL148161 | — | Ki | > | 1000.0 | nM | - |