Assay Detail
Binding
CHEMBL643763
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Evaluation of in vitro inhibitory activity against Angiotensin I converting enzyme
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Angiotensin-converting enzyme (CHEMBL4074) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
New alpha-thiol dipeptide dual inhibitors of angiotensin-I converting enzyme and neutral endopeptidase EC 3.4.24.11.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.66 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL320610 | — | — | 1 | 8.15 |
| CHEMBL577 | ENALAPRILAT ANHYDROUS | 4.0 | 1 | 8.06 |
| CHEMBL424497 | — | — | 1 | 8.00 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 8.00 |
| CHEMBL148911 | — | — | 1 | 7.96 |
| CHEMBL147899 | — | — | 1 | 7.96 |
| CHEMBL146652 | — | — | 1 | 7.89 |
| CHEMBL144543 | — | — | 1 | 7.82 |
| CHEMBL144549 | — | — | 1 | 7.82 |
| CHEMBL435421 | — | — | 1 | 7.77 |
| CHEMBL356123 | — | — | 1 | 7.75 |
| CHEMBL343691 | — | — | 1 | 7.72 |
| CHEMBL147702 | — | — | 1 | 7.66 |
| CHEMBL149364 | — | — | 1 | 7.62 |
| CHEMBL147595 | — | — | 1 | 7.58 |
| CHEMBL358592 | — | — | 1 | 7.52 |
| CHEMBL342321 | — | — | 1 | 7.48 |
| CHEMBL356343 | — | — | 1 | 7.46 |
| CHEMBL356084 | — | — | 1 | 7.43 |
| CHEMBL342993 | — | — | 1 | 7.24 |
| CHEMBL358338 | — | — | 1 | 7.21 |
| CHEMBL148368 | — | — | 1 | 7.19 |
| CHEMBL64081 | — | — | 1 | 6.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL320610 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL577 | ENALAPRILAT ANHYDROUS | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL424497 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL148911 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL147899 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL146652 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL144543 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL144549 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL435421 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL356123 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL343691 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL147702 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL149364 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL147595 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL358592 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL342321 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL356343 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL356084 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL342993 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL358338 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL148368 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL64081 | — | IC50 | = | 139.0 | nM | 6.86 |