Assay Detail
Binding
CHEMBL643765
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In vitro activity against angiotensin I converting enzyme especially against Hip-His-Leu residues
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Angiotensin-converting enzyme (CHEMBL4074) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Configuration and preferential solid-state conformations of perindoprilat (S-9780). Comparison with the crystal structures of other ACE inhibitors and conclusions related to structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.54 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL577 | ENALAPRILAT ANHYDROUS | 4.0 | 1 | 8.92 |
| CHEMBL347863 | — | — | 1 | 8.82 |
| CHEMBL161170 | — | — | 1 | 8.82 |
| CHEMBL2371228 | — | — | 1 | 8.72 |
| CHEMBL162360 | — | — | 1 | 7.64 |
| CHEMBL161660 | — | — | 1 | 6.70 |
| CHEMBL2371229 | — | — | 1 | 6.64 |
| CHEMBL349119 | — | — | 1 | 5.96 |
| CHEMBL348537 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL577 | ENALAPRILAT ANHYDROUS | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL347863 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL161170 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL2371228 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL162360 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL161660 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2371229 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL349119 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL348537 | — | IC50 | = | 2500.0 | nM | 5.60 |