Assay Detail
Binding
CHEMBL643766
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In vitro inhibition of Angiotensin I converting enzyme
64
Total Activities
63
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Angiotensin-converting enzyme (CHEMBL4074) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Angiotensin converting enzyme inhibitors: N-substituted monocyclic and bicyclic amino acid derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 64 | 7.45 | 8.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL610903 | — | — | 1 | 8.59 |
| CHEMBL611149 | — | — | 1 | 8.59 |
| CHEMBL1744333 | — | — | 1 | 8.37 |
| CHEMBL22198 | — | — | 1 | 8.33 |
| CHEMBL1744329 | — | — | 1 | 8.30 |
| CHEMBL1169540 | — | — | 1 | 8.26 |
| CHEMBL1744332 | — | — | 1 | 8.17 |
| CHEMBL1788148 | — | — | 1 | 8.15 |
| CHEMBL1788151 | — | — | 1 | 8.15 |
| CHEMBL22654 | — | — | 1 | 8.14 |
| CHEMBL1744325 | — | — | 1 | 8.12 |
| CHEMBL1788152 | — | — | 1 | 8.12 |
| CHEMBL1744334 | — | — | 1 | 8.11 |
| CHEMBL283586 | — | — | 1 | 8.10 |
| CHEMBL1788149 | — | — | 1 | 8.05 |
| CHEMBL282730 | — | — | 1 | 8.04 |
| CHEMBL23641 | — | — | 1 | 8.02 |
| CHEMBL23347 | — | — | 1 | 8.00 |
| CHEMBL23379 | — | — | 1 | 8.00 |
| CHEMBL23727 | — | — | 1 | 7.96 |
| CHEMBL1788147 | — | — | 1 | 7.92 |
| CHEMBL279938 | — | — | 1 | 7.92 |
| CHEMBL26338 | — | — | 1 | 7.89 |
| CHEMBL23527 | — | — | 1 | 7.89 |
| CHEMBL280420 | — | — | 1 | 7.82 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 7.82 |
| CHEMBL24814 | — | — | 1 | 7.80 |
| CHEMBL1744326 | — | — | 1 | 7.72 |
| CHEMBL1744320 | — | — | 1 | 7.72 |
| CHEMBL1744327 | — | — | 1 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL610903 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL611149 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL1744333 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL22198 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL1744329 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1169540 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL1744332 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL1788151 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1788148 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL22654 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL1744325 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL1788152 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL1744334 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL283586 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1788149 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL282730 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL23641 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL23347 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL23379 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL23727 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1788147 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL279938 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL26338 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL23527 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL280420 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL24814 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1744326 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1744320 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1744327 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1744336 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1788146 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1788150 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL23534 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1744324 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1744337 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL23555 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1744335 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL23102 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL22652 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1744317 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1744331 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL278559 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL23251 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1744330 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL1788153 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL282072 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL25771 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL1744322 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL23098 | — | IC50 | = | 93.0 | nM | 7.03 |