Assay Detail
Binding
CHEMBL643767
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In vitro inhibition of angiotensin I converting enzyme (ACE)
28
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Angiotensin-converting enzyme (CHEMBL4074) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Angiotensin converting enzyme inhibitors: 1-glutarylindoline-2-carboxylic acids derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.19 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL22430 | — | — | 1 | 8.32 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 7.82 |
| CHEMBL24368 | — | — | 1 | 7.55 |
| CHEMBL279733 | — | — | 1 | 7.48 |
| CHEMBL283757 | — | — | 1 | 7.41 |
| CHEMBL23748 | — | — | 1 | 7.36 |
| CHEMBL279658 | — | — | 1 | 7.30 |
| CHEMBL283988 | — | — | 2 | 7.27 |
| CHEMBL26168 | — | — | 1 | 7.19 |
| CHEMBL278160 | — | — | 1 | 6.96 |
| CHEMBL24064 | — | — | 1 | 6.58 |
| CHEMBL24008 | — | — | 1 | 6.52 |
| CHEMBL417286 | — | — | 1 | 6.36 |
| CHEMBL280697 | — | — | 1 | 6.04 |
| CHEMBL279497 | — | — | 1 | 5.37 |
| CHEMBL23667 | — | — | 1 | 5.32 |
| CHEMBL287218 | — | — | 1 | 5.26 |
| CHEMBL277188 | — | — | 1 | 5.16 |
| CHEMBL285221 | — | — | 1 | 5.06 |
| CHEMBL22429 | — | — | 1 | 4.96 |
| CHEMBL23376 | — | — | 1 | 4.96 |
| CHEMBL26169 | — | — | 1 | 4.80 |
| CHEMBL286060 | — | — | 1 | 4.55 |
| CHEMBL284932 | — | — | 1 | 4.43 |
| CHEMBL277919 | — | — | 1 | 4.16 |
| CHEMBL23494 | — | — | 1 | - |
| CHEMBL281352 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL22430 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL24368 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL279733 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL283757 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL23748 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL279658 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL283988 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL26168 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL278160 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL283988 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL24064 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL24008 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL417286 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL280697 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL279497 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL23667 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL287218 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL277188 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL285221 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL22429 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL23376 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL26169 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL286060 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL284932 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL277919 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL281352 | — | IC50 | = | 170000.0 | nM | - |
| CHEMBL23494 | — | IC50 | = | 290000.0 | nM | - |