Assay Detail
Binding
CHEMBL643769
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In vitro inhibition of rabbit lung Angiotensin I converting enzyme (ACE) using Hippuryl-His-Leu as substrate
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Angiotensin-converting enzyme (CHEMBL4074) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Mercaptoacyl dipeptides as dual inhibitors of angiotensin-converting enzyme and neutral endopeptidase. Preliminary structure-activity studies
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.07 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL299181 | — | — | 1 | 8.40 |
| CHEMBL50582 | — | — | 1 | 8.11 |
| CHEMBL50625 | — | — | 1 | 8.06 |
| CHEMBL50954 | — | — | 1 | 8.00 |
| CHEMBL51988 | — | — | 1 | 8.00 |
| CHEMBL49920 | — | — | 1 | 7.85 |
| CHEMBL422403 | — | — | 1 | 7.75 |
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 7.64 |
| CHEMBL50312 | — | — | 1 | 7.60 |
| CHEMBL287896 | — | — | 1 | 7.52 |
| CHEMBL51428 | — | — | 1 | 7.43 |
| CHEMBL50914 | — | — | 1 | 7.16 |
| CHEMBL50414 | — | — | 1 | 7.11 |
| CHEMBL51625 | — | — | 1 | 7.10 |
| CHEMBL51715 | — | — | 1 | 6.92 |
| CHEMBL50203 | — | — | 1 | 6.68 |
| CHEMBL300880 | — | — | 1 | 6.54 |
| CHEMBL50595 | — | — | 1 | 6.34 |
| CHEMBL50915 | — | — | 1 | 6.31 |
| CHEMBL295936 | — | — | 1 | 6.06 |
| CHEMBL51301 | — | — | 1 | 5.80 |
| CHEMBL440856 | — | — | 1 | 5.75 |
| CHEMBL51466 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL299181 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL50582 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL50625 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL50954 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL51988 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL49920 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL422403 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL50312 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL287896 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL51428 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL50914 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL50414 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL51625 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL51715 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL50203 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL300880 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL50595 | — | IC50 | = | 452.0 | nM | 6.34 |
| CHEMBL50915 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL295936 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL51301 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL440856 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL51466 | — | IC50 | = | 32000.0 | nM | 4.50 |