Assay Detail
Binding
CHEMBL643770
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against Angiotensin I converting enzyme (ACE) isolated from rabbit lung extract using hippuryl-L-histidyl-L-leucine (HHL) as the substrate
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Angiotensin-converting enzyme (CHEMBL4074) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Vasopeptidase inhibitors: incorporation of geminal and spirocyclic substituted azepinones in mercaptoacyl dipeptides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.94 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289556 | OMAPATRILAT | 2.0 | 1 | 8.30 |
| CHEMBL319237 | — | — | 1 | 8.22 |
| CHEMBL104054 | — | — | 1 | 8.09 |
| CHEMBL430484 | — | — | 1 | 8.02 |
| CHEMBL107747 | GEMOPATRILAT | 2.0 | 1 | 7.92 |
| CHEMBL318096 | — | — | 1 | 7.80 |
| CHEMBL299169 | — | — | 1 | 7.66 |
| CHEMBL107275 | — | — | 1 | 7.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289556 | OMAPATRILAT | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL319237 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL104054 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL430484 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL107747 | GEMOPATRILAT | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL318096 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL299169 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL107275 | — | IC50 | = | 29.0 | nM | 7.54 |