Assay Detail
Binding
CHEMBL643835
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Concentration required to inhibit Acyl coenzyme A:cholesterol acyltransferase 1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Human ACAT-1 and -2 inhibitory activities of saucerneol B, manassantin A and B isolated from Saururus chinensis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.10 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15611 | OLEIC ACID ANILIDE | — | 1 | 6.85 |
| CHEMBL316331 | — | — | 1 | 5.10 |
| CHEMBL431258 | — | — | 1 | 4.37 |
| CHEMBL321124 | — | — | 1 | 4.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15611 | OLEIC ACID ANILIDE | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL316331 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL431258 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL321124 | — | IC50 | = | 82000.0 | nM | 4.09 |