Assay Detail
Functional
CHEMBL643852
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonistic activity upon postsynaptic alpha-1 adrenergic receptor was determined in the rat isolated, field stimulated vas deferens using methoxamine
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Vas deferens |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 6.05 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | 7.24 |
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 6.52 |
| CHEMBL280514 | — | — | 1 | 6.20 |
| CHEMBL10347 | RAUWOLSCINE | — | 1 | 6.00 |
| CHEMBL18094 | — | — | 1 | 5.70 |
| CHEMBL17605 | — | — | 1 | 5.40 |
| CHEMBL18194 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6437 | MIANSERIN | Kd | = | 57.54 | nM | 7.24 |
| CHEMBL15245 | YOHIMBINE | Kd | = | 302.0 | nM | 6.52 |
| CHEMBL280514 | — | Kd | = | 630.96 | nM | 6.20 |
| CHEMBL10347 | RAUWOLSCINE | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL18094 | — | Kd | = | 1995.26 | nM | 5.70 |
| CHEMBL17605 | — | Kd | = | 3981.07 | nM | 5.40 |
| CHEMBL18194 | — | Kd | = | 5011.87 | nM | 5.30 |