Assay Detail
Functional
CHEMBL643857
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Methoxamine antagonistic activity against alpha-1 adrenergic receptor in isolated, field -simulated vas deferens from rats
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Vas deferens |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
alpha-Adrenergic activities of some substituted 2-(aminomethyl)imidazolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 7.23 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL597 | PHENTOLAMINE | 4.0 | 1 | 8.10 |
| CHEMBL51131 | — | — | 1 | 7.60 |
| CHEMBL541208 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL597 | PHENTOLAMINE | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL51131 | — | Kd | = | 25.12 | nM | 7.60 |
| CHEMBL541208 | — | Kd | = | 1000.0 | nM | 6.00 |