Assay Detail
Binding
CHEMBL643868
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Binding affinity against human Alpha-1b adrenergic receptor
22
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of novel dihydropyridine alpha-1a antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 22 | 6.46 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95548 | — | — | 1 | 7.75 |
| CHEMBL432026 | — | — | 1 | 7.44 |
| CHEMBL95263 | — | — | 1 | 6.90 |
| CHEMBL320736 | — | — | 1 | 6.75 |
| CHEMBL95736 | — | — | 1 | 6.74 |
| CHEMBL316495 | — | — | 1 | 6.74 |
| CHEMBL100045 | — | — | 1 | 6.72 |
| CHEMBL5483012 | — | — | 1 | 6.66 |
| CHEMBL323579 | — | — | 4 | 6.63 |
| CHEMBL95253 | — | — | 1 | 6.59 |
| CHEMBL95434 | — | — | 1 | 6.57 |
| CHEMBL99864 | — | — | 1 | 6.46 |
| CHEMBL180561 | — | — | 1 | 6.43 |
| CHEMBL95578 | — | — | 1 | 6.35 |
| CHEMBL330401 | — | — | 1 | 6.32 |
| CHEMBL95290 | — | — | 1 | 6.11 |
| CHEMBL322405 | — | — | 1 | 6.08 |
| CHEMBL1491 | AMLODIPINE | 4.0 | 1 | 5.10 |
| CHEMBL98038 | — | — | 1 | 4.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95548 | — | Ki | = | 17.9 | nM | 7.75 |
| CHEMBL432026 | — | Ki | = | 36.3 | nM | 7.44 |
| CHEMBL95263 | — | Ki | = | 127.0 | nM | 6.90 |
| CHEMBL320736 | — | Ki | = | 177.0 | nM | 6.75 |
| CHEMBL95736 | — | Ki | = | 181.0 | nM | 6.74 |
| CHEMBL316495 | — | Ki | = | 181.0 | nM | 6.74 |
| CHEMBL100045 | — | Ki | = | 192.0 | nM | 6.72 |
| CHEMBL5483012 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL323579 | — | Ki | = | 236.0 | nM | 6.63 |
| CHEMBL95253 | — | Ki | = | 254.0 | nM | 6.59 |
| CHEMBL95434 | — | Ki | = | 269.0 | nM | 6.57 |
| CHEMBL323579 | — | Ki | = | 326.0 | nM | 6.49 |
| CHEMBL323579 | — | Ki | = | 326.0 | nM | 6.49 |
| CHEMBL99864 | — | Ki | = | 347.0 | nM | 6.46 |
| CHEMBL180561 | — | Ki | = | 367.0 | nM | 6.43 |
| CHEMBL95578 | — | Ki | = | 447.0 | nM | 6.35 |
| CHEMBL330401 | — | Ki | = | 479.0 | nM | 6.32 |
| CHEMBL323579 | — | Ki | = | 505.0 | nM | 6.30 |
| CHEMBL95290 | — | Ki | = | 785.0 | nM | 6.11 |
| CHEMBL322405 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL1491 | AMLODIPINE | Ki | = | 7943.0 | nM | 5.10 |
| CHEMBL98038 | — | Ki | = | 38681.0 | nM | 4.41 |