Assay Detail
Binding
CHEMBL643905
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Binding affinity towards Alpha-1B adrenergic receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
SB-656104-A: a novel 5-HT(7) receptor antagonist with improved in vivo properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.44 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL430706 | — | — | 1 | 8.89 |
| CHEMBL114345 | — | — | 1 | 7.72 |
| CHEMBL413707 | — | — | 1 | 7.52 |
| CHEMBL115262 | — | — | 1 | 7.36 |
| CHEMBL331803 | — | — | 1 | 7.05 |
| CHEMBL116292 | — | — | 1 | 7.03 |
| CHEMBL323778 | — | — | 1 | 6.51 |
| CHEMBL330353 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL430706 | — | Ki | = | 1.288 | nM | 8.89 |
| CHEMBL114345 | — | Ki | = | 19.05 | nM | 7.72 |
| CHEMBL413707 | — | Ki | = | 30.2 | nM | 7.52 |
| CHEMBL115262 | — | Ki | = | 43.65 | nM | 7.36 |
| CHEMBL331803 | — | Ki | = | 89.13 | nM | 7.05 |
| CHEMBL116292 | — | Ki | = | 93.33 | nM | 7.03 |
| CHEMBL323778 | — | Ki | = | 309.03 | nM | 6.51 |
| CHEMBL330353 | — | Ki | < | 10000.0 | nM | - |