Assay Detail
Binding
CHEMBL643907
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity was evaluated against,[3H]clonidine (Clon) rat brain minus cerebellum Alpha-2 adrenergic receptor
5
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Resolution and absolute configuration of the potent dopamine agonist N,N-diethyl-N'-[(3 alpha, 4a alpha, 10a beta)-1,2,3,4,4a,5,10,10a- -octahydro-6-hydroxy-1-propyl-3-benzo[g]quinolinyl]sulfamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.77 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 6.37 |
| CHEMBL38992 | ETISULERGINE | 2.0 | 1 | 6.32 |
| CHEMBL2218861 | QUINAGOLIDE | 4.0 | 3 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL38992 | ETISULERGINE | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL2218861 | QUINAGOLIDE | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL2218861 | QUINAGOLIDE | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL2218861 | QUINAGOLIDE | IC50 | > | 10000.0 | nM | - |