Assay Detail
Binding
CHEMBL643909
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Inhibition of specific [3H]clonidine binding (0.4 nM) to rat brain membranes Alpha-2 adrenergic receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Quantitative relationships between alpha-adrenergic activity and binding affinity of alpha-adrenoceptor agonists and antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.10 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL597 | PHENTOLAMINE | 4.0 | 1 | 7.70 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 5.85 |
| CHEMBL31410 | CORYNANTHEINE | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL597 | PHENTOLAMINE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL31410 | CORYNANTHEINE | IC50 | = | 17500.0 | nM | 4.76 |