Assay Detail
Binding
CHEMBL643926
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Binding affinity towards Alpha-2 adrenergic receptor
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Novel pyridazino[4,5-b][1,5]oxazepines and -thiazepines as 5-HT1A receptor ligands
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.51 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL316490 | — | — | 1 | 6.57 |
| CHEMBL99523 | — | — | 1 | 6.27 |
| CHEMBL318857 | — | — | 1 | 6.07 |
| CHEMBL95832 | — | — | 1 | 5.75 |
| CHEMBL95837 | — | — | 1 | 5.63 |
| CHEMBL95310 | — | — | 1 | 5.51 |
| CHEMBL319937 | — | — | 1 | 5.41 |
| CHEMBL97618 | — | — | 1 | 5.34 |
| CHEMBL100260 | — | — | 1 | 5.02 |
| CHEMBL97711 | — | — | 1 | 4.68 |
| CHEMBL319600 | — | — | 1 | 4.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL316490 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL99523 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL318857 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL95832 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL95837 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL95310 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL319937 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL97618 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL100260 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL97711 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL319600 | — | IC50 | = | 47000.0 | nM | 4.33 |