Assay Detail
Binding
CHEMBL643937
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of bovine lens aldose reductase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member B1 (CHEMBL3081) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Computer-assisted design and synthesis of novel aldose reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.72 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL436 | TOLRESTAT | 4.0 | 1 | 7.46 |
| CHEMBL348759 | — | — | 1 | 6.57 |
| CHEMBL168106 | — | — | 1 | 6.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL436 | TOLRESTAT | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL348759 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL168106 | — | IC50 | = | 730.0 | nM | 6.14 |