Assay Detail
Binding
CHEMBL643947
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Binding affinity against human Alpha-1d adrenergic receptor was evaluated by cloned receptor binding assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Selective alpha-1a adrenergic receptor antagonists. Effects of pharmacophore regio- and stereochemistry on potency and selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.26 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8412 | IPSAPIRONE | 2.0 | 1 | 7.34 |
| CHEMBL418926 | — | — | 1 | 6.50 |
| CHEMBL82267 | — | — | 1 | 6.32 |
| CHEMBL3349545 | — | — | 1 | 5.96 |
| CHEMBL1169493 | — | — | 1 | 5.75 |
| CHEMBL79532 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8412 | IPSAPIRONE | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL418926 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL82267 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL3349545 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL1169493 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL79532 | — | Ki | = | 2000.0 | nM | 5.70 |