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Compound Detail

CHEMBL418926

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CCOC(=O)[C@H]1CN(CCCCN2C(=O)c3cc(Cl)ccc3S2(=O)=O)CC[C@@H]1c1ccccc1

Basic Information

ChEMBL ID CHEMBL418926
Phase Preclinical
Structure Type MOL
InChI Key IPBOROXXRHATRV-IRLDBZIGSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

505.0
MW (Da)
3.93
ALogP
6
HBA
0
HBD
84.0
PSA (Ų)
0.40
QED
1
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H29ClN2O5S
MW 505.04
Aromatic Rings 2
Heavy Atoms 34
NP-Likeness -1.03

Activity Summary

Ki 3 meas. best 7.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Alpha-1A adrenergic receptor
CHEMBL229
Ki 7.0 7.0 100.0 1
Alpha-1D adrenergic receptor
CHEMBL223
Ki 6.5 6.5 320.0 1
Alpha-1B adrenergic receptor
CHEMBL232
Ki 5.85 5.85 1400.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
9873568 10.1016/s0960-894x(98)00451-x Alpha-1A adrenergic receptor 1
9873568 10.1016/s0960-894x(98)00451-x Alpha-1B adrenergic receptor 1
9873568 10.1016/s0960-894x(98)00451-x Alpha-1D adrenergic receptor 1

Data from ChEMBL 36 via Core Engine