Assay Detail
Binding
CHEMBL648788
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Binding affinity against human Alpha-1a adrenergic receptor was evaluated by cloned receptor binding assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Selective alpha-1a adrenergic receptor antagonists. Effects of pharmacophore regio- and stereochemistry on potency and selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.71 | 9.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL82267 | — | — | 1 | 9.29 |
| CHEMBL1169493 | — | — | 1 | 8.52 |
| CHEMBL79532 | — | — | 1 | 7.36 |
| CHEMBL8412 | IPSAPIRONE | 2.0 | 1 | 7.06 |
| CHEMBL3349545 | — | — | 1 | 7.01 |
| CHEMBL418926 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL82267 | — | Ki | = | 0.51 | nM | 9.29 |
| CHEMBL1169493 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL79532 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL8412 | IPSAPIRONE | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL3349545 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL418926 | — | Ki | = | 100.0 | nM | 7.00 |