Assay Detail
Binding
CHEMBL643955
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Affinity to alpha-2 adrenergic receptor by the displacement of [3H]clonidine from calf cerebral cortex membranes
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-affinity relationships of arylquinolizines at alpha-adrenoceptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.68 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL346492 | — | — | 1 | 8.37 |
| CHEMBL158371 | — | — | 1 | 7.79 |
| CHEMBL345349 | — | — | 1 | 7.22 |
| CHEMBL346016 | — | — | 1 | 6.71 |
| CHEMBL160388 | — | — | 1 | 6.46 |
| CHEMBL345621 | — | — | 1 | 6.18 |
| CHEMBL348538 | — | — | 1 | 5.70 |
| CHEMBL156283 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL346492 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL158371 | — | Ki | = | 16.2 | nM | 7.79 |
| CHEMBL345349 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL346016 | — | Ki | = | 195.0 | nM | 6.71 |
| CHEMBL160388 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL345621 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL348538 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL156283 | — | Ki | = | 9600.0 | nM | 5.02 |